This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: DLSLVVPSAL FAAVGTAGQR CTTARRLFIH ESIHDEVVNR LKKAYAQIRV GNPWDPNVLY GPLHTKQAVS MFLGAVEEAK KEGGTVVYGG KVMDRPGNYV EPTIVTGLGH DASIAHTETF APILY
Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 89%.
The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 26g turgor protein homolog; aldehyde dehydrogenase 7 family, member A1; Aldehyde dehydrogenase family 7 member A1; Alpha-AASA dehydrogenase; Alpha-aminoadipic semialdehyde dehydrogenase; Antiquitin 1; Antiquitin-1; Antiquitin1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase
Gene Aliases: ALDH7A1; ATQ1; EPD; PDE
UniProt ID: (Human) P49419
Entrez Gene ID: (Human) 501
Molecular Function: dehydrogenase