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Product Details
21602-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ALDH8A1 Fusion Protein Ag16214 (136-487 aa encoded by BC113862)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: CMHYTVRAP VGVAGLISPW NLPLYLLTWK IAPAMAAGNT VIAKPSELTS VTAWMLCKLL DKAGVPPGVV NIVFGTGPRV GEALVSHPEV PLISFTGSQP TAERITQLSA PHCKKLSLEL GGKNPAIIFE DANLDECIPA TVRSSFANQG EICLCTSRIF VQKSIYSEFL KRFVEATRKW KVGIPSDPLV SIGALISKAH LEKVRSYVKR ALAEGAQIWC GEGVDKLSLP ARNQAGYFML PTVITDIKDE SCCMTEEIFG PVTCVVPFDS EEEVIERANN VKYGLAATVW SSNVGRVHRV AKKLQSGLVW TNCWLIRELN LPFGGMKSSG IGREGAKDSY DFFTEIKTIT VKH (136-487 aa encoded by BC113862)
Target Information
This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Two transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 2-aminomuconic semialdehyde dehydrogenase; Aldehyde dehydrogenase 12; aldehyde dehydrogenase 8 family, member A1; Aldehyde dehydrogenase family 8 member A1; aldehyde dehydrogenase family protein; Retinal dehydrogenase 4; retinal dehydrogenase type 4
Gene Aliases: ALDH12; ALDH8A1; DJ352A20.2; Raldh4
UniProt ID: (Human) Q9H2A2, (Mouse) Q8BH00
Entrez Gene ID: (Human) 64577, (Mouse) 237320, (Rat) 685750
retinal dehydrogenase activity
aldehyde dehydrogenase (NAD) activity
3-chloroallyl aldehyde dehydrogenase activity
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
1-hydroxy-2-naphthaldehyde dehydrogenase activity
cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity
2-carboxybenzaldehyde dehydrogenase activity
trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity
benzaldehyde dehydrogenase activity
2-naphthaldehyde dehydrogenase activity
1-naphthaldehyde dehydrogenase activity
4-hydroxymethylsalicyaldehyde dehydrogenase activity
3-methylsalicylaldehyde dehydrogenase activity
oxoglutarate dehydrogenase [NAD(P)+] activity
oxoglutarate dehydrogenase (NAD+) activity
pyruvate dehydrogenase [NAD(P)+] activity
pyruvate dehydrogenase (NAD+) activity
citronellal dehydrogenase activity
geranial dehydrogenase activity
N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity
glyceraldehyde dehydrogenase (NADP) activity
N-acetyl-gamma-aminoadipyl-phosphate reductase activity
glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
2,5-dioxovalerate dehydrogenase (NAD+) activity
medium-chain-aldehyde dehydrogenase activity
dehydrogenase
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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