This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Two transcript variants encoding distinct isoforms have been identified for this gene.
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Protein Aliases: 2-aminomuconic semialdehyde dehydrogenase; Aldehyde dehydrogenase 12; aldehyde dehydrogenase 8 family, member A1; Aldehyde dehydrogenase family 8 member A1; aldehyde dehydrogenase family protein; ALDH12; ALDH8A1; Retinal dehydrogenase 4; retinal dehydrogenase type 4
Gene Aliases: ALDH12; ALDH8A1; DJ352A20.2; Raldh4