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Proteintech
ALDOB Polyclonal Antibody
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Product Details
18065-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ALDOB Fusion Protein Ag12695 (1-316 aa encoded by BC029399)
Conjugate
Form
Liquid
Concentration
0.41 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAHRFPALT QEQKKELSEI AQSIVANGKG ILAADESVGT MGNRLQRIKV ENTEENRRQF REILFSVDSS INQSIGGVIL FHETLYQKDS QGKLFRNILK EKGIVVGIKL DQGGAPLAGT NKETTIQGLD GLSERCAQYK KDGVDFGKWR AVLRIADQCP SSLPIQENAN ALARYASICQ QNGLVPIVEP EVIPDGDHDL EHCQYVTEKV LAAVYKALND HHVYLEGTLL KPNMVTAGHA CTKKYTPEQV AMATVTALHR TVPAAVPGIC FLSGGMSEED ATLNLNAINL CPLPKPWKLS FSGVARLQTR RQPRRLL (1-316 aa encoded by BC029399)
Target Information
Fructose-1,6-bisphosphate aldolase is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Aldolase 2; aldolase 2, B isoform; Aldolase B fructose-biphosphate; Aldolase B, fructose-biphosphate; aldolase B, fructose-bisphosphatase; aldolase B, fructose-bisphosphate; Fructose-bisphosphate aldolase B; Liver-type aldolase
Gene Aliases: ALDB; Aldo-2; ALDO2; ALDOB; BC016435; LIV10
UniProt ID: (Human) P05062, (Mouse) Q91Y97
Entrez Gene ID: (Human) 229, (Mouse) 230163, (Rat) 24190
liver development
fructose metabolic process
gluconeogenesis
glycolytic process
NADH oxidation
response to fructose
response to zinc ion
fructose 1,6-bisphosphate metabolic process
cellular response to extracellular stimulus
positive regulation of ATPase activity
cellular response to insulin stimulus
response to drug
response to starvation
response to amino acid
response to copper ion
response to glucocorticoid
response to cAMP
canonical glycolysis
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
vacuolar proton-transporting V-type ATPase complex assembly
response to interleukin-6
response to peptide hormone
response to carbohydrate
response to organic cyclic compound
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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