This Antibody was verified by IP-mass spectrometry to ensure that the antibody binds to the antigen stated. View Details
The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246; CD246 antigen; EC 184.108.40.206; kinase ALK; mutant anaplastic lymphoma kinase; npm-alk; TFG/ALK
Gene Aliases: ALK; CD246; NBLST3
UniProt ID: (Human) Q9UM73
Entrez Gene ID: (Human) 238