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Proteintech
ALKBH3 Polyclonal Antibody
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Product Details
12292-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ALKBH3 Fusion Protein Ag2982 (148-286 aa encoded by BC015155)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Amount
43.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEPNPHWHP VLRTLKNRIE ENTGHTFNSL LCNLYRNEKD SVDWHSDDEP SLGRCPIIAS LSFGATRTFE MRKKPPPEEN GDYTYVERVK IPLDHGTLLI MEGATQADWQ HRVPKEYHSR EPRVNLTFRT VYPDPRGAPW (148-286 aa encoded by BC015155)
Target Information
Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AlkB homolog 3; alkB homolog 3, alpha-ketoglutaratedependent dioxygenase; alkB, alkylation repair homolog 3; Alkylated DNA repair protein alkB homolog 3; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; DEPC 1; DEPC-1; FLJ43614; hABH3; m MGC118790; mAbh3; MGC118792; MGC118793; MGC134125; Prostate cancer antigen 1; prostate cancer antigen-1; RP23-375N21.4
Gene Aliases: 1700108H04Rik; 1810020C19Rik; ABH3; ALKBH3; DEPC-1; DEPC1; hABH3; mABH3; PCA1
UniProt ID: (Human) Q96Q83, (Rat) Q5XIC8, (Mouse) Q8K1E6
Entrez Gene ID: (Human) 221120, (Rat) 362169, (Mouse) 69113
protein binding
ferrous iron binding
oxidoreductase activity
L-ascorbic acid binding
oxidative RNA demethylase activity
oxidative DNA demethylase activity
metal ion binding
dioxygenase activity
RNA N1-methyladenosine dioxygenase activity
endonuclease activity
exonuclease activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
DNA-N1-methyladenine dioxygenase activity
cytosine C-5 DNA demethylase activity
sulfonate dioxygenase activity
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
oxygenase
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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