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Proteintech
ALKBH7 Polyclonal Antibody
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Product Details
15470-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ALKBH7 Fusion Protein Ag7772 (1-221 aa encoded by BC004393)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAGTGLLAL RTLPGPSWVR GSGPSVLSRL QDAAVVRPGF LSTAEEETLS RELEPELRRR RYEYDHWDAA IHGFRETEKS RWSEASRAIL QRVQAAAFGP GQTLLSSVHV LDLEARGYIK PHVDSIKFCG ATIAGLSLLS PSVMRLVHTQ EPGEWLELLL EPGSLYILRG SARYDFSHEI LRDEESFFGE RRIPRGRRIS VICRSLPEGM GPGESGQPPP AC (1-221 aa encoded by BC004393)
Target Information
ALKBH7 (alkB, alkylation repair homolog 7), also known as SPATA11, is a 221 amino acid protein belonging to the alkB family. ALKBH7 is one of many homologs of the Escherichia coli protein AlkB. AlkB functions to protect DNA and RNA against damage from environmental methylating compounds by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzyme acts by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate and molecular oxygen as the oxidizing agent. ALKBH7 is encoded by a gene located on human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognizedfor having the greatest gene density of the human chromosomes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alkB, alkylation repair homolog 7; Alkylated DNA repair protein alkB homolog 7; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial; pre-tRNA N1-methyl adenine demethylase ALKBH7; pre-tRNA N2-dimethyl guanosine demethylase ALKBH7; probable alpha-ketoglutarate-dependent dioxygenase ABH7; RNA demethylase ALKBH7, mitochondrial; spermatogenesis associated 11; spermatogenesis cell proliferation related protein; Spermatogenesis cell proliferation-related protein; Spermatogenesis-associated protein 11; unnamed protein product
Gene Aliases: 2310045B01Rik; 2510008E23Rik; ABH7; ALKBH7; SPATA11; UNQ6002; UNQ6002/PRO34564
UniProt ID: (Human) Q9BT30, (Mouse) Q9D6Z0
Entrez Gene ID: (Human) 84266, (Mouse) 66400, (Rat) 679944
protein binding
oxidoreductase activity
metal ion binding
dioxygenase activity
sulfonate dioxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
procollagen-proline dioxygenase activity
hypophosphite dioxygenase activity
DNA-N1-methyladenine dioxygenase activity
C-19 gibberellin 2-beta-dioxygenase activity
C-20 gibberellin 2-beta-dioxygenase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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