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THRAP3 is a 955 amino acid novel nuclear receptor and a member of the Thyroid hormone receptor associated proteins with a LISH domain and no obvious known sequence motifs. THRAP3 is a 150 kDa subunit of the large multiprotein complex TRAP and is important in the maintenance of the fundamental structure of the fibrillar center and dense fibrillar component in the nucleolus. It is also known to play an important role in transcriptional coactivation. It is known to interact with DKC1, nop5/nap65 and fibrillarin. From the Northern blot analysis of several human tissues it was found that TRAP150 is ubiquitously expressed.
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Protein Aliases: Alstrom syndrome 1; Alstrom syndrome protein 1; DKFZp686A118; DKFZp686D1828
Gene Aliases: ALMS1; ALSS; KIAA0328
UniProt ID: (Human) Q8TCU4
Entrez Gene ID: (Human) 7840