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Invitrogen

ALOX15B Polyclonal Antibody

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ALOX15B Polyclonal Antibody

Product Details

PA5-93250

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:5,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein (or fragment)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.25 mg/mL

Amount

125 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2806693

Product Specific Information

Positive Samples: HL-60, Mouse ovary; Cellular Location: Cell membrane, Cytoplasm, Membrane, Nucleus, Peripheral membrane protein, cytoskeleton, cytosol

Immunogen sequence: MAEFRVRVST GEAFGAGTWD KVSVSIVGTR GESPPLPLDN LGKEFTAGAE EDFQVTLPED VGRVLLLRVH KAPPVLPLLG PLAPDAWFCR WFQLTPPRGG HLLFPCYQWL EGAGTLVLQE GTAKVSWADH HPVLQQQRQE ELQARQEMYQ WKAYNPGWPH CLDEKTVEDL ELNIKYSTAK NANFYLQAGS AFAEMKIKGL

Target Information

ALOX15B encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 15-lipoxygenase 2; 15-LOX-2; 15-LOX-B; 15-LOX2sv-a; 15-LOX2sv-b; 15-LOX2sv-c; 15S-lipoxygenase; 8-LOX; 8S-lipoxygenase; arachidonate 15-lipoxygenase 2; Arachidonate 15-lipoxygenase B; Arachidonate 15-lipoxygenase type II; arachidonate 15-lipoxygenase, second type; Arachidonate 8S-lipoxygenase; arachidonate omega(6) lipoxygenase; Linoleate 13-lipoxygenase 15-LOb; Linoleate 9S-lipoxygenase ALOX8; Polyunsaturated fatty acid lipoxygenase ALOX15B; Polyunsaturated fatty acid lipoxygenase ALOX8; unnamed protein product

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Gene Aliases: 15-LOX-2; 15-LOX-B; 8-LOX; 8S-LOX; ALOX15B; Alox8

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UniProt ID: (Human) O15296, (Rat) Q8K4F2, (Mouse) O35936

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Entrez Gene ID: (Human) 247, (Rat) 266604, (Mouse) 11688

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Function(s)
iron ion binding calcium ion binding protein binding lipid binding linoleate 13S-lipoxygenase activity oxidoreductase activity oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen arachidonate 8(S)-lipoxygenase activity metal ion binding arachidonate 15-lipoxygenase activity dioxygenase activity linoleate 9S-lipoxygenase activity 2,3-dihydroxy DDT 1,2-dioxygenase activity phenanthrene dioxygenase activity 2,2',3-trihydroxybiphenyl dioxygenase activity 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity protocatechuate 3,4-dioxygenase type II activity 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity carbazole 1,9a-dioxygenase activity dihydroxydibenzothiophene dioxygenase activity 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity styrene dioxygenase activity 3,4-dihydroxyphenanthrene dioxygenase activity hydroquinone 1,2-dioxygenase activity p-cumate 2,3-dioxygenase activity 2,3-dihydroxy-p-cumate dioxygenase activity 3,5-dichlorocatechol 1,2-dioxygenase activity 2-aminophenol 1,6-dioxygenase activity 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity chlorocatechol 1,2-dioxygenase activity catechol dioxygenase activity dihydroxyfluorene dioxygenase activity 5-aminosalicylate dioxygenase activity 3-hydroxy-2-naphthoate 2,3-dioxygenase activity benzo(a)pyrene 11,12-dioxygenase activity benzo(a)pyrene 4,5-dioxygenase activity 4,5-dihydroxybenzo(a)pyrene dioxygenase activity benzo(a)pyrene 9,10-dioxygenase activity 9,10-dihydroxybenzo(a)pyrene dioxygenase activity benzo(a)pyrene 7,8-dioxygenase activity 7,8-dihydroxy benzo(a)pyrene dioxygenase activity 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity 2-mercaptobenzothiazole dioxygenase activity pyridine-3,4-diol dioxygenase activity pyrene dioxygenase activity 4,5-dihydroxypyrene dioxygenase activity phenanthrene-4-carboxylate dioxygenase activity tetrachlorobenzene dioxygenase activity 4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity 2,3-dihydroxydiphenyl ether dioxygenase activity diphenyl ether 1,2-dioxygenase activity 4-hydroxycatechol 1,2-dioxygenase activity arachidonate 8(R)-lipoxygenase activity oxygenase
Process(es)
lipid metabolic process phospholipid metabolic process apoptotic process negative regulation of cell proliferation positive regulation of macrophage derived foam cell differentiation arachidonic acid metabolic process lipoxygenase pathway negative regulation of cell migration prostate gland development regulation of epithelial cell differentiation positive regulation of chemokine production lipid oxidation positive regulation of peroxisome proliferator activated receptor signaling pathway linoleic acid metabolic process positive regulation of keratinocyte differentiation negative regulation of cell cycle negative regulation of growth hepoxilin biosynthetic process endocannabinoid signaling pathway cannabinoid biosynthetic process lipoxin A4 biosynthetic process oxidation-reduction process positive regulation of chemokine secretion
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