This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
In direct ELISAs and Western blots, approximately 60% cross-reactivity with recombinant human ALPL is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alkaline phosphatase; Alkaline phosphatase 2; alkaline phosphatase 2, liver; Alkaline phosphatase liver/bone/kidney isozyme; Alkaline phosphatase, tissue-nonspecific isozyme; alkaline phosphomonoesterase; AP-TNAP; APTNAP; glycerophosphatase; HOPS; liver/bone/kidney-type alkaline phosphatase; tissue-nonspecific ALP; tissue-nonspecific isozyme; TNAP; TNSALP
Gene Aliases: Akp-2; Akp2; ALPL; AP-TNAP; APTNAP; HOPS; TNAP; TNSALP