Proteintech

ALR Polyclonal Antibody

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ALR Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human colon cancer using 11293-1-AP (ALR antibody) at dilution of 1:100 (under 10x lens).

ALR Antibody in Western Blot (WB) — Mouse liver tissue were subjected to SDS PAGE followed by western blot with 11293-1-AP (ALR antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

ALR Antibody in Immunoprecipitation (IP) — IP result of anti-ALR (IP:11293-1-AP, 3ug; Detection:11293-1-AP 1:1000) with mouse liver tissue lysate 4000ug.

Product Details

11293-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	View 9 publications 9 publications
Immunohistochemistry (IHC)	-	View 1 publication 1 publication
Immunohistochemistry (Paraffin) (IHC (P))	1:20-1:200	-
Immunocytochemistry (ICC/IF)	-	View 4 publications 4 publications
Flow Cytometry (Flow)	Assay-dependent	View 1 publication 1 publication
Immunoprecipitation (IP)	0.5-4.0 µg	-
Miscellaneous PubMed (Misc)	-	View 2 publications 2 publications

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	ALR Fusion Protein Ag1840 (1-125 aa encoded by BC028348) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.36 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.1% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: MRTQQKRDT KFREDCPPDR EELGRHSWAV LHTLAAYYPD LPTPEQQQDM AQFIHLFSKF YPCEECAEDL RKRLCRNHPD TRTRACFTQW LCHLHNEVNR KLGKPDFDCS KVDERWRDGW KDGSCD (1-125 aa encoded by B C028348)

Target Information

Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Augmenter of liver regeneration protein deficiency promotes hepatic steatosis by inducing oxidative stress and microRNA-540 expression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Kumar S,Rani R,Karns R,Gandhi CR

Fri Mar 01 00:00:00 EST 2019

Augmenter of liver regeneration protein deficiency promotes hepatic steatosis by inducing oxidative stress and microRNA-540 expression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Kumar S,Rani R,Karns R,Gandhi CR

Fri Mar 01 00:00:00 EST 2019

Deficiency in augmenter of liver regeneration accelerates liver fibrosis by promoting migration of hepatic stellate cell.

Biochimica et biophysica acta. Molecular basis of disease

Ai WL,Dong LY,Wang J,Li ZW,Wang X,Gao J,Wu Y,An W

Thu Nov 01 00:00:00 EDT 2018

Deficiency in augmenter of liver regeneration accelerates liver fibrosis by promoting migration of hepatic stellate cell.

Biochimica et biophysica acta. Molecular basis of disease

Ai WL,Dong LY,Wang J,Li ZW,Wang X,Gao J,Wu Y,An W

Thu Nov 01 00:00:00 EDT 2018

Alleviation of palmitic acid-induced endoplasmic reticulum stress by augmenter of liver regeneration through IP3R-controlled Ca²⁺ release.

Journal of cellular physiology

Xiao WC,Zhang J,Chen SL,Shi YJ,Xiao F,An W

Wed Aug 01 00:00:00 EDT 2018

Lack of hepatic stimulator substance expression promotes hepatocellular carcinoma metastasis partly through ERK-activated epithelial-mesenchymal transition.

Laboratory investigation; a journal of technical methods and pathology

Jia XW,Li ZW,Dong LY,Sun GY,Wang X,Gao J,Li YP,Wu Y,An W

Sun Jul 01 00:00:00 EDT 2018

Augmenter of liver regeneration potentiates doxorubicin anticancer efficacy by reducing the expression of ABCB1 and ABCG2 in hepatocellular carcinoma.

Laboratory investigation; a journal of technical methods and pathology

Guo YY,Wu Y,Jia XW,An W

Fri Dec 01 00:00:00 EST 2017

Augmenter of liver regeneration potentiates doxorubicin anticancer efficacy by reducing the expression of ABCB1 and ABCG2 in hepatocellular carcinoma.

Laboratory investigation; a journal of technical methods and pathology

Guo YY,Wu Y,Jia XW,An W

Fri Dec 01 00:00:00 EST 2017

Augmenter of liver regeneration potentiates doxorubicin anticancer efficacy by reducing the expression of ABCB1 and ABCG2 in hepatocellular carcinoma.

Laboratory investigation; a journal of technical methods and pathology

Guo YY,Wu Y,Jia XW,An W

Fri Dec 01 00:00:00 EST 2017

Augmenter of Liver Regeneration Gene Therapy Using a Novel Minicircle DNA Vector Alleviates Liver Fibrosis in Rats.

Human gene therapy

Wu X,Liu G,Mu M,Peng Y,Li X,Deng L,Zhang Z,Chen M,You S,Kong X

Tue Nov 01 00:00:00 EDT 2016

Hepatic Deficiency of Augmenter of Liver Regeneration Exacerbates Alcohol-Induced Liver Injury and Promotes Fibrosis in Mice.

PloS one

Kumar S,Wang J,Rani R,Gandhi CR

Mon Jul 11 00:00:00 EDT 2016

The Level of ALR is Regulated by the Quantity of Mitochondrial DNA.

Pathology oncology research : POR

Balogh T,Lőrincz T,Stiller I,Mandl J,Bánhegyi G,Szarka A

Fri Apr 01 00:00:00 EDT 2016

Megakaryocytic differentiation of K562 cells induced by PMA reduced the activity of respiratory chain complex IV.

PloS one

Huang R,Zhao L,Chen H,Yin RH,Li CY,Zhan YQ,Zhang JH,Ge CH,Yu M,Yang XM

Mon Oct 19 00:00:00 EDT 2015

Gfer inhibits Jab1-mediated degradation of p27kip1 to restrict proliferation of hematopoietic stem cells.

Molecular biology of the cell

Teng EC,Todd LR,Ribar TJ,Lento W,Dimascio L,Means AR,Sankar U

Fri Apr 15 00:00:00 EDT 2011

Gfer inhibits Jab1-mediated degradation of p27kip1 to restrict proliferation of hematopoietic stem cells.

Molecular biology of the cell

Teng EC,Todd LR,Ribar TJ,Lento W,Dimascio L,Means AR,Sankar U

Fri Apr 15 00:00:00 EDT 2011

The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency.

American journal of human genetics

Di Fonzo A,Ronchi D,Lodi T,Fassone E,Tigano M,Lamperti C,Corti S,Bordoni A,Fortunato F,Nizzardo M,Napoli L,Donadoni C,Salani S,Saladino F,Moggio M,Bresolin N,Ferrero I,Comi GP

Fri May 01 00:00:00 EDT 2009

The mitochondrial disulfide relay system protein GFER is mutated in autosomal-recessive myopathy with cataract and combined respiratory-chain deficiency.

American journal of human genetics

Di Fonzo A,Ronchi D,Lodi T,Fassone E,Tigano M,Lamperti C,Corti S,Bordoni A,Fortunato F,Nizzardo M,Napoli L,Donadoni C,Salani S,Saladino F,Moggio M,Bresolin N,Ferrero I,Comi GP

Fri May 01 00:00:00 EDT 2009

Bioinformatics

Protein Aliases: Augmenter of liver regeneration; ERV1 homolog; erv1-like growth factor; FAD-linked sulfhydryl oxidase ALR; growth factor, erv1 homolog; growth factor, erv1-like (augmenter of liver regeneration); hepatic regenerative stimulation substance; Hepatopoietin; hepatopoietin protein; hERV1

Gene Aliases: ALR; ERV1; GFER; HERV1; HPO; HPO1; HPO2; HSS; MNCb-0663

UniProt ID: (Human) P55789, (Rat) Q63042, (Mouse) P56213

Entrez Gene ID: (Human) 2671, (Rat) 27100, (Mouse) 11692

Molecular Function: oxidase oxidoreductase metabolite interconversion enzyme