Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
PA1-4314 detects the PAPK protein in mouse samples.
PA1-4314 has been successfully used in Western blot procedures.
The PA1-4314 immunizing peptide corresponds to amino acid residues 399-418 of the mouse PAPK protein.
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog; ILP-interacting protein homolog; MGC102916; polyploidy associated protein kinase; Polyploidy-associated protein kinase; Pseudokinase ALS2CR2; STE20-related kinase adapter protein beta; STRAD beta
Gene Aliases: AA792893; Als2cr2; B830008M19; D1Ucla2; ILPIP; ILPIPA; Papk; PRO1038; Stradb; Syradb
UniProt ID: (Mouse) Q8K4T3
Entrez Gene ID: (Mouse) 227154
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support