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      ALS2CR2 Polyclonal Antibody

      See 7 other ALS2CR2 antibodies ›
      ALS2CR2 Polyclonal Antibody for Western Blot, IF, ICC and IHC (P)

      Catalog#: PA5-28635 Invitrogen

      Catalog # Size Price (USD) Qty Datasheet
      PA5-28635 100 µL
      349.00
      Please enter a quantity in the range of 1 to 199.
      Suggested Secondary Antibodies

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      Product Details

      Bioinformatics

      Documents
      Details
      Tested species reactivity Human
      Host / Isotype Rabbit / IgG
      Class Polyclonal
      Type Antibody
      Immunogen Synthetic peptide corresponding to a region within amino acids 356 and 418 of Human ALS2CR2
      Conjugate Unconjugated
      Form Liquid
      Concentration 1.03 mg/ml
      Purification Antigen affinity chromatography
      Storage buffer 0.1M tris glycine, pH 7, with 10% glycerol
      Contains 0.01% thimerosal
      Storage Conditions -20° C, Avoid Freeze/Thaw Cycles
      Tested Applications Dilution *
      Immunocytochemistry (ICC) Assay-Dependent
      Immunofluorescence (IF) Assay-Dependent
      Immunohistochemistry (Paraffin) (IHC (P)) 1:100-1:1000
      Western Blot (WB) 1:500-1:3000

      * Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.

      Product Specific Information

      PA5-28635 targets ALS2CR2 in IHC (P) and WB applications and shows reactivity with Human samples.

      The PA5-28635 immunogen is synthetic peptide corresponding to a region within amino acids 356 and 418 of Human ALS2CR2.

      Background/Target Information

      This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene.

      For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

      Bioinformatics

      Protein Aliases:

      ALS2CR2; amyotrophic lateral sclerosis 2 (juvenile) chromosome region; amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; CALS-21; candidate 2; ILP-interacting protein; ILP-interacting protein ILPIPA; ILPIP; ILPIPA; PAPK; Pseudokinase ALS2CR2; STE20-related kinase adapter protein beta; STRAD beta

      Gene Aliases:

      ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK; PRO1038; STRADB

      UniProt ID:

      (Human) Q9C0K7

      Entrez Gene ID:

      (Human) 55437

      Function(s) Process(es)

      Documents

      Material safety data sheets (MSDS)

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