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Invitrogen
ALX3 Polyclonal Antibody
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FIGURE: 1 / 3
ALX3 Antibody (PA5-36138) in IHC (P)
Immunohistochemistry analysis of ALX3 in paraffin-embedded human kidney carcinoma tissue (nucleus staining) and negative control (right, with PBS only). Samples were incubated with ALX3 polyclonal antibody (Product # PA5-36138) at a dilution of 1:50, followed by goat Anti-Rabbit IgG-biotin and avidin peroxidase.
Product Details
PA5-36138
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 171-220 of human ALX3
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 36 kDa.
Purity is >95% by SDS-PAGE.
Target Information
Aristaless-related genes are a group of paired-related homeobox genes which play a role in regulating vertebrate embryogenesis. The homeodomain transciption factor aristaless-like 3 (ALX3) is expressed in mouse embryos from 8 days of gestation, predominantly in neural crest-derived mesenchyme and in lateral plate mesoderm. Expression analysis of human and mouse tissue reveals predominant ALX3 expression in brain tissue. The Alx3 gene maps to chromosome 1p23-p13 and encodes a 343 amino acid protein. Preferential methylation of Alx3 occurs in advanced-stage neuroblastoma and may repress ALX3 expression. Treatment with the methylation inhibitor 5-aza-2'-deoxycytidine restores ALX3 expression. Alx3 (-) mice lack a phenotype distinct from wild-type mice, however Alx3/Alx4 double mutants demonstrate severe craniofacial abnormalities not present in Alx4 single mutants. Specifically, Alx3/Alx4 double mutant newborn mice have cleft nasal regions in addition to malformation of other neural crest-derived skull structures.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aristaless 3; aristaless-like homeobox 3; frontonasal dysplasia; Homeobox protein aristaless-like 3; Proline-rich transcription factor ALX3
Gene Aliases: ALX3; FND; FND1
UniProt ID: (Human) O95076, (Mouse) O70137
Entrez Gene ID: (Human) 257, (Mouse) 11694, (Rat) 365900
transcription, DNA-templated
regulation of transcription, DNA-templated
pattern specification process
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
regulation of apoptotic process
embryonic cranial skeleton morphogenesis
multicellular organism development
embryonic skeletal system morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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