In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant rat MIS RII is observed, and less than 1% cross-reactivity with recombinant human TGF-beta RI, RII, RIII, and RIIB is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
The AMH receptor (AMHR or AMHR2) is a serine/threonine kinase with a single transmembrane domain belonging to the family of type II receptors for TGF-beta-related proteins. Anti-Mullerian hormone (AMH) and its receptor are involved in the regression of Mullerian ducts in male fetuses. Male sex differentiation is mediated by 2 discrete hormones produced by the fetal testis. Testosterone, produced by Leydig cells, virilizes the external genitalia and promotes prostatic growth, anti-Mullerian hormone (AMH) results in regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AMH type II receptor; AMHR; AMHR2; Anti-Muellerian hormone type II receptor; Anti-Muellerian hormone type II receptor [Precursor]; Anti-Muellerian hormone type-2 receptor; anti-Mullerian hormone receptor type II; anti-Mullerian hormone receptor, type II; MIS type II receptor; MISRII; MRII; Muellerian inhibiting substance type II receptor; Mullerian inhibiting substance type II receptor
Gene Aliases: AMHR; AMHR2; MISR2; MISRII; MRII
UniProt ID: (Human) Q16671
Entrez Gene ID: (Human) 269