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Product Details
24550-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
AMOT Fusion Protein Ag19784 (769-1084 aa encoded by BC130294)
Conjugate
Form
Liquid
Concentration
0.57 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
AMOT has two isoforms with MW 130 kDa (p130) and 80 kDa (p80). The p130 isoform can interact with F-actin. This antibody recognizes both p130 and p80.
Immunogen sequence: RKEPSKTEQ LSCMRPAKSL MSISNAGSGL LSHSSTLTGS PIMEEKRDDK SWKGSLGILL GGDYRAEYVP STPSPVPPST PLLSAHSKTG SRDCSTQTER GTESNKTAAV APISVPAPVA AAATAAAITA TAATITTTMV AAAPVAVAAA AAPAAAAAPS PATAAATAAA VSPAAAGQIP AAASVASAAA VAPSAAAAAA VQVAPAAPAP VPAPALVPVP APAAAQASAP AQTQAPTSAP AVAPTPAPTP TPAVAQAEVP PASPATGPGP HRLSIPSLTC NPDKTDGPVF HSNTLERKTP IQILGQEPDA EMVEYLI (769-1084 aa encoded by BC130294)
Target Information
AMOT (Angiomotin) belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. AMOT plays a central role in tight junction maintenance via the complex formed with ARHGAP17 - which acts by regulating the uptake of polarity proteins at tight junctions. AMOT is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Angiomotin; angiomotin p130 isoform; angiomotin p80 isoform
Gene Aliases: AMOT; KIAA1071
UniProt ID: (Human) Q4VCS5
Entrez Gene ID: (Human) 154796
vasculogenesis
in utero embryonic development
gastrulation with mouth forming second
establishment of cell polarity involved in ameboidal cell migration
chemotaxis
negative regulation of angiogenesis
actin cytoskeleton organization
regulation of cell migration
negative regulation of GTPase activity
cellular protein localization
hippo signaling
positive regulation of embryonic development
cell migration involved in gastrulation
blood vessel endothelial cell migration
regulation of small GTPase mediated signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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