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Immunogen sequence: SPSACYSPSS PVQVLEDSTY FSPDFQLYSG RHETSALTVE ATSSIREKVV EDPLCNFHSP NFLRISEVEM RGSEDAAAGT VLQRLIQEQL RYGTPTENMN LLAIQHQATG SAGPAHPTNN FSSTENLTQE DPQMVYQSAR QEPQGQEHQV
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 32%.
The protein encoded by this gene is a peripheral membrane protein that is a component of tight junctions or TJs. TJs form an apical junctional structure and act to control paracellular permeability and maintain cell polarity. This protein is related to angiomotin, an angiostatin binding protein that regulates endothelial cell migration and capillary formation. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Angiomotin-like protein 1; junction-enriched and associated protein
Gene Aliases: AMOTL1; JEAP
UniProt ID: (Human) Q8IY63
Entrez Gene ID: (Human) 154810
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