Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
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Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Angiomotin-like protein 2; LCCP; Leman coiled-coil protein
Gene Aliases: AMOTL2; KIAA0989; LCCP
UniProt ID: (Human) Q9Y2J4
Entrez Gene ID: (Human) 51421
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