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Proteintech
ANAPC7 Polyclonal Antibody
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Product Details
21761-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ANAPC7 fusion protein Ag16339
Conjugate
Form
Liquid
Concentration
450 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: QMLDPYLIKG MDVYGYLLAR EGRLEDVENL GCRLFNISDQ HAEPWVVSGC HSFYSKRYSR ALYLGAKAIQ LNSNSVQALL LKGAALRNMG RVQEAIIHFR EAIRLAPCRL DCYEGLIECY LASNSIREAM VIANNVYKTL GANAQTLTLL ATVCLEDPVT QEKAKTLLDK ALTQRPDYIK AVVKKAELLS REQKYEDGIA LLRNALANQS DCVLHRILGD FLVAVNEYQE AMDQYSIALS LDPNDQKSLE GMQKMEKEES PTDATQEEDV DDMEGSGEEG DLEGSDSEAA QWADQEQWFG MQ
Target Information
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC7 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC7 is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with various transcription coactivators.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
mitotic nuclear division
anaphase-promoting complex-dependent catabolic process
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
cell division
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
protein K11-linked ubiquitination
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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