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Proteintech
ANK1 Polyclonal Antibody
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Product Details
23938-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MWTFVTQLLV TLVLLSFFLV SCQNVMHIVR GSLCFVLKHI HQELDKELGE SEDLSDDEET ISTRVVRRRV FLKGNEFQNI PGEQVTEEQF TDEQGNIVTK KIIRKVVRQI DLSSADAAQE HEEVELRGSG LQPDLIEGRK GAQIVKRASL KRGKQ
Target Information
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANK-1; ankyrin 1, erythrocytic; Ankyrin-1; Ankyrin-R; Attaches integral membrane proteins to cytoskeletal elements; Erythrocyte ankyrin; normoblastic anemia; rCG_43073; unnamed protein product
Gene Aliases: ANK; Ank-1; ANK1; ankyrin-1; nb; pale; SPH1; SPH2
UniProt ID: (Human) P16157, (Mouse) Q02357
Entrez Gene ID: (Human) 286, (Mouse) 11733
exocytosis
ER to Golgi vesicle-mediated transport
cytoskeleton organization
signal transduction
positive regulation of organelle organization
maintenance of epithelial cell apical/basal polarity
Golgi vesicle transport
protein localization to plasma membrane
porphyrin-containing compound biosynthetic process
monovalent inorganic cation transport
erythrocyte development
iron ion homeostasis
protein targeting to plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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