Peptide sequence: SDLGYYIINK LHHVDESVGS KTRRAFLYLA AFPFMDAMAW THAGILLKHK
Sequence homology: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%
ANKH is a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals.
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Protein Aliases: ANK; ANKH inorganic pyrophosphate transport regulator; Ankylosis; ankylosis, progressive homolog; ankylosis, progressive homolog (mouse); CCAL2; CMDJ; CPPDD; FLJ27166; Fn54 protein; HANK; MANK; progressive ankylosis homolog; Progressive ankylosis protein; Progressive ankylosis protein homolog; progressive homolog (mouse)
Gene Aliases: ANK; ANKH; BOS_19912; CCAL2; CMDJ; CPPDD; D15Ertd221e; HANK; KIAA1581; MANK; mKIAA1581; UNQ241/PRO274