Immunogen sequence: LGYYKNIHDI IPDRSGPELG GDATIRKMLS FWWPLALILA TQRISRPIVN LFVSRDLGGS SAATEAVAIL TATYPVGHMP YGWLTEIRAV YPAFDKNNPS NKLVSTSNTV T; Positive Samples: SH-SY5Y, OVCAR-3 ; Cellular Location: Membrane, Multi-pass membrane protein
ANKH is a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals.
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Protein Aliases: ANK; ankylosis, progressive homolog; Progressive ankylosis protein homolog
Gene Aliases: ANK; ANKH; CCAL2; CMDJ; CPPDD; HANK; KIAA1581; MANK; UNQ241/PRO274
UniProt ID: (Human) Q9HCJ1
Entrez Gene ID: (Human) 56172