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Immunogen sequence: RRLCRLVQE GRLRALKEEL QAAGGCPGPA GDTLLHCAAR HGHRDVLAYL AEAWGMDIEA TNRDYKRPLH EAASMGHRDC VRYLLGRGAA VDCLKKADWT PLMMACTRKN LGVIQELVEH GANPLLKNKD GWNSFHIASR EGDPLILQYL LTVCPGAWKT ESKIRRTPLH TAAMHGHLEA VKVLLKRCQY EPDYRDNCGV TALMDAIQCG HIDVARLLLD EHGACLSAED SLGAQALHRA AVTGQDEAIR FLVSELGVDV DVRATSTHLT ALHYAAKEGH TSTIQTLLSL GADINSKDEK NRSALHLACA GQHLACAKFL LQSGLKDSED ITGTLAQQLP RRADVLQGSG HSAMT (8-361 aa encoded by BC062346)
Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity. Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Ankyrin repeat domain-containing protein 16
Gene Aliases: 2810455F06Rik; AI646698; ANKRD16; D430029B21Rik
UniProt ID: (Human) Q6P6B7, (Mouse) A2AS55
Entrez Gene ID: (Human) 54522, (Mouse) 320816
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