Ankyrin (ANK) repeats mediate protein-protein interactions in diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20. ANK repeats may occur in combinations with other types of domains. The structural repeat unit contains two anti-parallel helices and a beta-hairpin, with repeats stacked in a superhelical arrangement. LIAR, also known as ANKRD54, is a recently identified ANK repeat-containing protein that is predominantly expressed in tissues rich in ciliated cells, such as olfactory sensory neurons and is predicted to be important to cilia. At least three isoforms of LIAR are known to exist.
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Protein Aliases: Ankyrin repeat domain-containing protein 54; Lyn-interacting ankyrin repeat protein
Gene Aliases: ANKRD54; C730048E16Rik; EST1068184; EST475269; LIAR; RGD1309552