Peptide sequence: ACAKMRANCQ KSTEQMKKVP TIILSVSYKG VKFIDATNKN IIAEHEIRNI
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AIDA; AIDA-1; amyloid-beta precursor protein intracellular domain associated protein 1; Amyloid-beta protein intracellular domain-associated protein 1; ANKS2; ankyrin repeat and sterile alpha motif domain containing 1B; Ankyrin repeat and sterile alpha motif domain-containing protein 1B; cajalin 2; cajalin 2-like; cajalin-2; E2A-PBX1-associated protein; EB-1; MGC26087
Gene Aliases: AIDA; AIDA-1; AIDA-1b; ANKS1B; ANKS2; BOS_5288; C030032C09Rik; cajalin-2; E530015N03Rik; EB-1; EB1; ENSMUSG00000078431; Gm10937; Gm1555; RGD1565556
Molecular Function: transmembrane receptor regulatory/adaptor protein