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Rockland
ANOSMIN Polyclonal Antibody
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FIGURE: 1 / 3
ANOSMIN Antibody (600-401-Y18) in ICC/IF
Immunocytochemistry of Rabbit Anti-Anosmin. Cells: MCF7 cells (W09-000-360). Primary Antibody: Anti-Anosmin antibody at 5 µg/mL in 1% BSA diluent for 1hr at RT. Secondary Antibody: anti-rabbit biotin-conjugated 1:200 in 1% BSA diluent for 1hr at RT. Wash. Add streptavidin‐HRP for 30 min at RT. Detection: DAB solution. Counter stain: hematoxylin for 30 seconds.
Product Details
600-401-Y18
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-Anosmin antibody was prepared from whole rabbit serum produced by repeated immunizations with an 18 amino acid synthetic peptide near the internal region of human Anosmin.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
KAL1 (Anosmin-1) an extracellular matrix-associated glycosylated protein, have been linked with Kallmann Syndrome (KS), an X-linked genetic disorder characterized by loss of smell caused by abnormal olfactory bulb development and delayed puberty caused by disrupted migration of the gonadotropin-releasing hormone neuron. Anosmin-1 has been shown to directly bind FGFR1 via its N-terminal cysteine-rich domain, whey-acidic protein-like domain, and its first FnIII repeat with the D2 and D3 ectodomains of FGFR1. It is thought that Anosmin-1 can modulate FGFR1 signaling and have opposing effects on the formation and activation of FGF2-FGFR1-heparing complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Adhesion molecule-like X-linked; anosmin; Anosmin-1; Anosmin1; Kallmann syndrome interval gene 1; Kallmann syndrome protein; Kallmann syndrome-1 sequence (anosmin-1); WAP four-disulfide core domain 19
Gene Aliases: ADMLX; ANOS1; HH1; HHA; KAL; KAL1; KALIG-1; KALIG1; KMS; WFDC19
UniProt ID: (Human) P23352
Entrez Gene ID: (Human) 3730
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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