Immunogen sequence: GQTRANPMYN AVSNADLMDF KNLLDHLEEK MPLEDEVVPP QVLSEPNEEA GAALSPLPEV PPWT
Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 78%.
The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6.
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Protein Aliases: ANF; ANP; ATFB6; Atrial natriuretic factor; Atrial natriuretic peptide; atriopeptin; Cardiodilatin; Cardiodilatin-related peptide; cardionatrin; CDD; CDD-ANF; CDP; natriuretic peptide precursor A; natriuretic peptide precursor A variant 1; Natriuretic peptides A; PND; Prepronatriodilatin
Gene Aliases: ANF; ANP; ATFB6; ATRST2; CDD; CDD-ANF; CDP; NPPA; PND
UniProt ID: (Human) P01160
Entrez Gene ID: (Human) 4878