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Alomone Labs, LTD

SORL1 (extracellular) Polyclonal Antibody

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SORL1 (extracellular) Polyclonal Antibody

Product Details

ANR-132-200UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:300
-

Flow Cytometry (Flow)

5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

(C)KRRTPHAT(S)FNGED, corresponding to amino acid residues 652-665 of human SORL1, Extracellular, N-terminus
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.8 mg/mL

Amount

160 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Target Information

This gene encodes a mosaic protein that belongs to at least two families: the vacuolar protein sorting 10 domain-containing receptor family, and the low density lipoprotein receptor family. The encoded protein also contains fibronectin type III repeats and an epidermal growth factor repeat. The encoded protein is translated as a preproprotein and likely plays roles in endocytosis and sorting. There may be an association between expression of this locus and Alzheimer's Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ21930; FLJ39258; Gp250; LDLR relative with 11 ligand-binding repeats; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; mosaic protein LR11; mSorLA; SorLA; SorLA-1; Sortilin-related receptor; sortilin-related receptor, L(DLR class) A repeats containing; Sorting protein-related receptor containing LDLR class A repeats; unnamed protein product

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Gene Aliases: 2900010L19Rik; AI596264; AW261561; C11orf32; gp250; LR11; LRP9; mSorLA; RGD619914; SORL1; SORLA; SorLA-1

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UniProt ID: (Human) Q92673, (Rat) P0DSP1, (Mouse) O88307

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Entrez Gene ID: (Human) 6653, (Rat) 300652, (Mouse) 20660

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Function(s)
beta-amyloid binding transmembrane signaling receptor activity low-density lipoprotein receptor activity protein binding aspartic-type endopeptidase inhibitor activity low-density lipoprotein particle binding small GTPase binding neuropeptide binding protein transporter activity ADP-ribosylation factor binding apolipoprotein membrane traffic protein
Process(es)
diet induced thermogenesis protein targeting protein targeting to lysosome post-Golgi vesicle-mediated transport endocytosis receptor-mediated endocytosis neuropeptide signaling pathway negative regulation of triglyceride catabolic process regulation of smooth muscle cell migration cell migration negative regulation of BMP signaling pathway negative regulation of protein complex assembly protein localization to Golgi apparatus beta-amyloid formation insulin receptor recycling retrograde transport, endosome to Golgi protein retention in Golgi apparatus positive regulation of protein catabolic process positive regulation of insulin receptor signaling pathway negative regulation of neurogenesis positive regulation of protein exit from endoplasmic reticulum endosome to plasma membrane protein transport positive regulation of glial cell-derived neurotrophic factor secretion negative regulation of beta-amyloid formation positive regulation of ER to Golgi vesicle-mediated transport positive regulation of early endosome to recycling endosome transport positive regulation of protein localization to early endosome negative regulation of amyloid precursor protein catabolic process negative regulation of neurofibrillary tangle assembly positive regulation of adipose tissue development adaptive thermogenesis positive regulation of endocytic recycling protein targeting to Golgi cell proliferation negative regulation of protein binding negative regulation of protein oligomerization negative regulation of MAP kinase activity protein maturation negative regulation of neuron death positive regulation of choline O-acetyltransferase activity negative regulation of tau-protein kinase activity negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process lipid metabolic process transport lipid transport multicellular organism development steroid metabolic process cholesterol metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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