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Proteintech
ANT1/2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
15997-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ANT1/2 Fusion Protein Ag7787 (1-298 aa encoded by BC008664)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.33 mg/mL
Amount
49.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes both of ANT1 and ANT2.
Immunogen sequence: MGDHAWSFL KDFLAGGVAA AVSKTAVAPI ERVKLLLQVQ HASKQISAEK QYKGIIDCVV RIPKEQGFLS FWRGNLANVI RYFPTQALNF AFKDKYKQLF LGGVDRHKQF WRYFAGNLAS GGAAGATSLC FVYPLDFART RLAADVGKGA AQREFHGLGD CIIKIFKSDG LRGLYQGFNV SVQGIIIYRA AYFGVYDTAK GMLPDPKNVH IFVSWMIAQS VTAVAGLVSY PFDTVRRRMM MQSGRKGADI MYTGTVDCWR KIAKDEGAKA FFKGAWSNVL RGMGGAFVLV LYDEIKKYV (1-298 aa encoded by BC008664 )
Target Information
Adenine nucleotide translocator (ANT) and the voltage-dependent anion-selective channel proteins 1 and 2 (VDAC1 and VDAC2) are components of the permeability transition pore complex (PTPC) of the mitochondrial inner and outer membranes, respectively. Formation of PTPCs, the subsequent dissipation of mitochondrial inner membrane potential and release of cytochrome c through the outer mitochondrial membrane are critical events in the early stages of apoptosis. Bax, a proapoptotic protein, has been shown to act upon ANT to induce the dissipation of mitochondrial inner membrane potential. ANT1 has a role in the maintenance of mitochondrial DNA by catalyzing the exchange of ADP and ATP across the mitochondrial inner membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adenine nucleotide translocase; adenine nucleotide translocase-1; adenine nucleotide translocator 1; adenine nucleotide translocator 1 (skeletal muscle); adenine nucleotide translocator 1, skeletal muscle; adenine nucleotide translocator 2 (fibroblast); adenine nucleotide translocator 2, fibroblast; adenine nucleotide translocator), member 4; adenine nucleotide translocator), member 5; ADP, ATP carrier protein 2; ADP,ATP carrier protein 1; ADP,ATP carrier protein 2; ADP,ATP carrier protein, heart/skeletal muscle; ADP.ATP translocase; ADP/ADT translocator protein; ADP/ATP carrier 1; ADP/ATP carrier protein; ANT 1; ANT 2; heart/skeletal muscle ATP/ADP translocator; mitochondrial adenine nucleotide translocator; mitochondrial carrier adenine nucleotide translocator; progressive external ophthalmoplegia 2; progressive external ophthalmoplegia 3; solute carrier family 25 (mitochondrial adenine nucleotide translocator) member 4; solute carrier family 25 (mitochondrial carrier; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator) member 4 isoform SLC25A4_1; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator) member 4 isoform SLC25A4_2; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator) member 4 isoform SLC25A4_3; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5; solute carrier family 25 member 4; unnamed protein product
Gene Aliases: 2F1; AAC1; AAC2; ANT; ANT 1; ANT1; ANT2; mANC1; MTDPS12; MTDPS12A; PEO2; PEO3; PEOA2; T1; T2; T3
UniProt ID: (Human) P12235, (Human) P05141, (Mouse) P48962, (Rat) Q05962, (Rat) Q09073, (Mouse) P51881
Entrez Gene ID: (Human) 291, (Human) 292, (Mouse) 11739, (Rat) 85333, (Rat) 25176, (Mouse) 11740
apoptotic mitochondrial changes
negative regulation of cardiac muscle cell apoptotic process
ADP transport
regulation of mitochondrial membrane permeability
transmembrane transport
negative regulation of necroptotic process
positive regulation of cell growth involved in cardiac muscle cell development
mitochondrial ADP transmembrane transport
positive regulation of mitophagy
negative regulation of mitochondrial membrane permeability involved in apoptotic process
hydrogen ion transmembrane transport
mitochondrial ATP transmembrane transport
adaptive thermogenesis
positive regulation of oxidative phosphorylation uncoupler activity
positive regulation of cell proliferation
adenine transport
B cell differentiation
erythrocyte differentiation
adenine nucleotide transport
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
cellular response to leukemia inhibitory factor
generation of precursor metabolites and energy
liver development
heart development
response to interleukin-1
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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