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Product Details
17796-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:200-1:1,000 | View 1 publication 1 publication |
Immunohistochemistry (IHC) |
- | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
ANT1/2 Fusion Protein Ag11956 (1-298 aa encoded by BC056160) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.45 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
This antibody recognizes both of ANT1 and ANT2. The predicted molecular weight of ANT1/2 protein is around 32 kDa. While 60 kDa protein can also be observed, which has been proposed as the dimmer of ANT1/2.
Immunogen sequence: MTDAAVSFA KDFLAGGVAA AISKTAVAPI ERVKLLLQVQ HASKQITADK QYKGIIDCVV RIPKEQGVLS FWRGNLANVI RYFPTQALNF AFKDKYKQIF LGGVDKRTQF WRYFAGNLAS GGAAGATSLC FVYPLDFART RLAADVGKAG AEREFRGLGD CLVKIYKSDG IKGLYQGFNV SVQGIIIYRA AYFGIYDTAK GMLPDPKNTH IVISWMIAQT VTAVAGLTSY PFDTVRRRMM MQSGRKGTDI MYTGTLDCWR KIARDEGGKA FFKGAWSNVL RGMGGAFVLV LYDEIKKYT (1-298 aa encoded by BC056160 )
Target Information
Adenine nucleotide translocator (ANT) and the voltage-dependent anion-selective channel proteins 1 and 2 (VDAC1 and VDAC2) are components of the permeability transition pore complex (PTPC) of the mitochondrial inner and outer membranes, respectively. Formation of PTPCs, the subsequent dissipation of mitochondrial inner membrane potential and release of cytochrome c through the outer mitochondrial membrane are critical events in the early stages of apoptosis. Bax, a proapoptotic protein, has been shown to act upon ANT to induce the dissipation of mitochondrial inner membrane potential. ANT1 has a role in the maintenance of mitochondrial DNA by catalyzing the exchange of ADP and ATP across the mitochondrial inner membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Adenine nucleotid translocator 2 fibroblast isoform (ATP-ADP carrier protein); Adenine nucleotid translocator 2, fibroblast isoform (ATP-ADP carrier protein); adenine nucleotide translocase-1; Adenine nucleotide translocator 1; adenine nucleotide translocator 1 (skeletal muscle); adenine nucleotide translocator 1, skeletal muscle; Adenine nucleotide translocator 2; adenine nucleotide translocator 2 (fibroblast); adenine nucleotide translocator 2 fibroblast isoform (ATP-ADP carrier protein); adenine nucleotide translocator 2, fibroblast isoform (ATP-ADP carrier protein); ADP,ATP carrier protein 1; ADP,ATP carrier protein 2; ADP,ATP carrier protein, fibroblast isoform; ADP,ATP carrier protein, heart/skeletal muscle; ADP,ATP carrier protein, heart/skeletal muscle isoform T1; ADP/ATP translocase 1; ADP/ATP translocase 2; ADP/ATP translocase 2, N-terminally processed; ANT 1; ANT 2; heart/skeletal muscle ATP/ADP translocator; mANC1; mitochondrial adenine nucleotide translocator; solute carrier family 25 (mitochondrial adenine nucleotide translocator) member 4; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5; Solute carrier family 25 member 4; Solute carrier family 25 member 5
Gene Aliases: 2F1; AAC1; AAC2; Anc1; ANT; ANT 1; ANT1; ANT2; AU019225; MTDPS12; PEO2; PEO3; PEOA2; SLC25A4; SLC25A5; T1; T2; T3
UniProt ID: (Human) P12235, (Human) P05141, (Rat) Q05962, (Mouse) P48962, (Rat) Q09073, (Mouse) P51881
Entrez Gene ID: (Human) 291, (Human) 292, (Rat) 85333, (Mouse) 11739, (Rat) 25176, (Mouse) 11740
Molecular Function:
transfer/carrier protein
mitochondrial genome maintenance
generation of precursor metabolites and energy
translation
transport
apoptotic mitochondrial changes
adenine transport
viral process
regulation of insulin secretion
transmembrane transport
negative regulation of necroptotic process
chromosome segregation
positive regulation of cell proliferation
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
liver development
heart development
aging
negative regulation of cardiac muscle cell apoptotic process
positive regulation of cell growth involved in cardiac muscle cell development
response to interleukin-1
negative regulation of mitochondrial membrane permeability involved in apoptotic process
positive regulation of oxidative phosphorylation uncoupler activity
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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