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Alomone Labs, LTD

mu-Opioid Receptor/OPRM1 (extracellular) Polyclonal Antibody, FITC

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mu-Opioid Receptor/OPRM1 (extracellular) Polyclonal Antibody, FITC

Product Details

AOR-011-F-15UL

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

2.5 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

CSPAPGSWLNLSHVDGN, corresponding to amino acid residues 22-38 of the rat mu-Opioid receptor, Extracellular, N-terminus
3D Epitope / Immunogen

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra spectra

Form

Lyophilized

Concentration

0.8 mg/mL

Amount

12 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 1% BSA

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles, store in dark

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitution: 15 µL or 50 µL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

Target Information

The OPRM1 gene encodes the mu opioid receptor, which is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone. It is also the primary receptor for endogenous opioid peptides beta-endorphin and the enkephalins. The OPRM1 receptor is a membrane of the G protein-coupled receptor family. There are at least 3 types of opioid receptors, mu, kappa, and delta, each with a distinct pharmacologic profile.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: G-protein coupled receptor; GPCR; GPCR; MOR-1K1; hMOP; KIAA0403; M-OR-1; MOP; MOP receptor; MOR-1; MOR-1C; MOR1; MOR3; Mu opiate receptor; Mu opioid receptor; mu opioid receptor hMOR-1a; mu opioid receptor splice variant mMOR-1Z; mu opioid receptor splice variant rMOR-1S; mu opioid receptor splice variant rMOR-1Z; Mu-type opioid receptor; MUOR1; Opioid mu receptor; Opioid Receptor; Opioid receptor B; OTTHUMP00000017463; unnamed protein product

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Gene Aliases: LMOR; M-OR-1; MOP; MOP-R; MOR; MOR-1; MOR-1O; MOR1; MORA; muOR; OPRM; OPRM1; Oprrm1; Ror-b

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UniProt ID: (Human) P35372, (Rat) P33535, (Mouse) P42866

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Entrez Gene ID: (Human) 4988, (Rat) 25601, (Mouse) 18390

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Function(s)
G-protein alpha-subunit binding G-protein coupled receptor activity beta-endorphin receptor activity opioid receptor activity voltage-gated calcium channel activity protein binding G-protein coupled peptide receptor activity G-protein beta-subunit binding morphine receptor activity neuropeptide binding protein domain specific binding filamin binding signal transducer activity protein C-terminus binding G-protein coupled receptor transmembrane signal receptor
Process(es)
signal transduction G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway neuropeptide signaling pathway sensory perception negative regulation of cell proliferation sensory perception of pain opioid receptor signaling pathway negative regulation of nitric oxide biosynthetic process behavioral response to ethanol positive regulation of neurogenesis negative regulation of cytosolic calcium ion concentration negative regulation of Wnt protein secretion positive regulation of ERK1 and ERK2 cascade calcium ion transmembrane transport cellular response to morphine regulation of cellular response to stress regulation of N-methyl-D-aspartate selective glutamate receptor activity acute inflammatory response to antigenic stimulus immune response adenylate cyclase-activating dopamine receptor signaling pathway negative regulation of adenylate cyclase activity positive regulation of cytosolic calcium ion concentration locomotory behavior adenylate cyclase-inhibiting opioid receptor signaling pathway response to food positive regulation of appetite response to lipopolysaccharide wound healing response to cocaine response to morphine positive regulation of cAMP-mediated signaling negative regulation of cAMP-mediated signaling positive regulation of nitric oxide biosynthetic process response to ethanol regulation of sensory perception of pain excitatory postsynaptic potential response to growth factor chemical synaptic transmission negative regulation of cAMP biosynthetic process cellular response to stress eating behavior
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