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Invitrogen
AOX1 Polyclonal Antibody
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Product Details
PA5-101413
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human AOX1(Accession Q06278), corresponding to amino acid residues K525-H575.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total AOX1.
Target Information
AOX1 (Aldehyde oxidase 1) is a 1338 amino acid cytoplasmic protein that catalyzes the oxidation of a variety of aldehydes, leading to the production of hydrogen peroxide. Under certain conditions, AOX1 can catalyze the formation of the superoxide free radical. Defects in oxygen radical metabolism have been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS), an autosomal dominant neurodegenerative disorder characterized by the death of motor neurons in the spinal cord, brain and brainstem. Significantly, AOX1 is highly expressed in the ventral horn of the spinal cord and the gene that encodes AOX1 is located in a chromosomal region that is frequently found to be implicated in ALS2. This evidence suggests that AOX1 is a candidate gene for ALS2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Aldehyde oxidase; aldehyde oxidase (female form); Aldehyde oxidase 1; aldehyde oxidase 2; Azaheterocycle hydroxylase; Azaheterocycle hydroxylase 1; Retinal oxidase
Gene Aliases: AI196512; AI255253; AO; AOH1; Aox-1; Aox-2; AOX1; Aox2; Moro; Ro
UniProt ID: (Human) Q06278, (Mouse) O54754, (Rat) Q9Z0U5
Entrez Gene ID: (Human) 316, (Mouse) 11761, (Rat) 54349
aldehyde oxidase activity
xanthine dehydrogenase activity
iron ion binding
electron carrier activity
oxidoreductase activity, acting on CH-OH group of donors
molybdopterin cofactor binding
flavin adenine dinucleotide binding
NAD binding
2 iron, 2 sulfur cluster binding
catalytic activity
UDP-N-acetylmuramate dehydrogenase activity
oxidoreductase activity
metal ion binding
iron-sulfur cluster binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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