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AP2 alpha + beta Polyclonal Antibody

View all (2) AP2 alpha/beta antibodies

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Additional Information:

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Product Details

BS-12480R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Flow Cytometry (Flow)

1:20-1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human AP2 alpha + beta.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome. Three transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activating enhancer binding protein 2 beta; activating enhancer-binding protein 2 alpha; activating enhancer-binding protein 2 beta; activating enhancer-binding protein 2-alpha; activator protein 2; AP-2 beta; AP-2 transcription factor; AP2-alpha; AP2-beta; DNA-binding protein (AP-2); FLJ51761; transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); unnamed protein product

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Gene Aliases: AP-2; Ap-2 (a); AP-2(beta); AP-2alpha; AP-2B; AP-2beta; Ap2; AP2-B; AP2-beta; AP2alpha; AP2TF; BOFS; E130018K07Rik; PDA2; Tcfap2a; Tcfap2b; TFAP2

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UniProt ID: (Human) P05549, (Human) Q92481, (Mouse) P34056, (Mouse) Q61313

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Entrez Gene ID: (Human) 7020, (Human) 7021, (Mouse) 21418, (Rat) 306862, (Rat) 301285, (Mouse) 21419

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding identical protein binding sequence-specific DNA binding transcription regulator inhibitor activity sequence-specific double-stranded DNA binding core promoter proximal region sequence-specific DNA binding protein homodimerization activity protein heterodimerization activity transcription coactivator activity transcription corepressor activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter kidney development glucose metabolic process regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter nervous system development sensory organ development positive regulation of cell proliferation negative regulation of cell proliferation gene expression retina layer formation regulation of BMP signaling pathway forelimb morphogenesis hindlimb morphogenesis aorta morphogenesis regulation of cell proliferation negative regulation of apoptotic process positive regulation of neuron apoptotic process skin development fat cell differentiation regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter sympathetic nervous system development smooth muscle tissue development regulation of insulin secretion distal tubule development collecting duct development metanephric nephron development ductus arteriosus closure response to xenobiotic stimulus negative regulation of neuron apoptotic process skeletal system development neural tube closure lens morphogenesis in camera-type eye outflow tract morphogenesis keratinocyte development optic vesicle morphogenesis optic cup structural organization sensory perception of sound embryonic pattern specification embryonic body morphogenesis positive regulation of gene expression neural crest cell development anterior neuropore closure trigeminal nerve development oculomotor nerve formation forebrain neuron development positive regulation of cell migration positive regulation of bone mineralization response to lipopolysaccharide embryonic forelimb morphogenesis negative regulation of epidermal growth factor receptor signaling pathway inner ear morphogenesis regulation of neuron differentiation embryonic camera-type eye morphogenesis embryonic cranial skeleton morphogenesis skeletal system morphogenesis epidermis morphogenesis palate development lens induction in camera-type eye face morphogenesis bone morphogenesis eyelid development in camera-type eye cornea development in camera-type eye positive regulation of tooth mineralization cellular response to iron ion basement membrane organization negative regulation of reactive oxygen species metabolic process Schwann cell development
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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