Invitrogen

AP2 alpha/beta Polyclonal Antibody

View all (2) AP2 alpha/beta antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
Tech Support
Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

PA5-99259

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TFAP2A(Accession P05549), corresponding to amino acid residues K411-K437.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818192

Product Specific Information

Antibody detects endogenous levels of total AP2 alpha/beta.

Target Information

The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome. Three transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activating enhancer binding protein 2 beta; activating enhancer-binding protein 2 alpha; activating enhancer-binding protein 2 beta; Activating enhancer-binding protein 2-alpha; Activating enhancer-binding protein 2-beta; Activator protein 2; AP-2; AP-2 transcription factor; AP2-alpha; AP2-beta; FLJ51761; transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); transcription factor AP-2 beta (activating enhancer binding protein 2 beta); Transcription factor AP-2-alpha; Transcription factor AP-2-beta

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Gene Aliases: AI606113; AP-2; Ap-2 (a); AP-2(beta); AP-2alpha; AP-2B; Ap2; AP2-B; AP2alpha; AP2TF; BOFS; E130018K07Rik; Tcfap2a; Tcfap2b; TFAP2; TFAP2A; TFAP2B

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UniProt ID: (Human) P05549, (Human) Q92481, (Mouse) P34056, (Mouse) Q61313

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Entrez Gene ID: (Human) 7020, (Human) 7021, (Mouse) 21418, (Rat) 306862, (Mouse) 21419, (Rat) 301285

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding transcription coactivator activity protein binding transcription factor binding protein homodimerization activity sequence-specific DNA binding transcription regulatory region DNA binding protein dimerization activity transcription factor activity, RNA polymerase II core promoter sequence-specific RNA polymerase II transcription coactivator activity RNA polymerase II transcription corepressor activity enhancer sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein heterodimerization activity RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding general transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter kidney development optic vesicle morphogenesis optic cup structural organization transcription from RNA polymerase II promoter sensory perception of sound negative regulation of cell proliferation response to water deprivation positive regulation of gene expression retina layer formation negative regulation of transcription by competitive promoter binding Schwann cell development trigeminal nerve development oculomotor nerve formation positive regulation of bone mineralization response to lipopolysaccharide embryonic forelimb morphogenesis inner ear morphogenesis negative regulation of apoptotic process positive regulation of neuron apoptotic process regulation of cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter embryonic cranial skeleton morphogenesis palate development bone morphogenesis eyelid development in camera-type eye positive regulation of tooth mineralization cellular response to iron ion negative regulation of reactive oxygen species metabolic process renal water homeostasis glucose metabolic process regulation of transcription, DNA-templated apoptotic process positive regulation of cell proliferation response to lithium ion magnesium ion homeostasis regulation of BMP signaling pathway forelimb morphogenesis hindlimb morphogenesis positive regulation of urine volume aorta morphogenesis response to drug glucose homeostasis negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of neuron apoptotic process skin development fat cell differentiation sympathetic nervous system development regulation of insulin secretion phosphate ion homeostasis calcium ion homeostasis potassium ion homeostasis sodium ion homeostasis distal tubule development collecting duct development metanephric nephron development ductus arteriosus closure cellular ammonia homeostasis cellular creatinine homeostasis cellular urea homeostasis neural tube closure lens morphogenesis in camera-type eye outflow tract morphogenesis keratinocyte development transcription, DNA-templated regulation of transcription from RNA polymerase II promoter embryonic pattern specification embryonic body morphogenesis neural crest cell development anterior neuropore closure forebrain neuron development positive regulation of cell migration negative regulation of epidermal growth factor receptor signaling pathway regulation of neuron differentiation embryonic camera-type eye morphogenesis skeletal system morphogenesis epidermis morphogenesis lens induction in camera-type eye face morphogenesis cornea development in camera-type eye basement membrane organization response to organic substance regulation of cell proliferation anatomical structure development
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