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Product Details
PA5-111042
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human AP2 beta. Recombinant protein control fragment (Product #RP-95302).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2856453
Product Specific Information
Immunogen sequence: QRQRQEVGSE AGSLLPQPRA ALPQLSGLDP RRDYHSVRRP DVLLHSAHHG LDAGMG
Target Information
This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activating enhancer binding protein 2 beta; Activating enhancer-binding protein 2-beta; AP2-beta; transcription factor AP-2 beta (activating enhancer binding protein 2 beta); Transcription factor AP-2-beta
Gene Aliases: AP-2B; AP2-B; TFAP2B
UniProt ID: (Human) Q92481
Entrez Gene ID: (Human) 7021
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II core promoter sequence-specific
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II transcription coactivator activity
RNA polymerase II transcription corepressor activity
enhancer sequence-specific DNA binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription corepressor activity
protein binding
protein homodimerization activity
cysteine-type endopeptidase inhibitor activity involved in apoptotic process
sequence-specific DNA binding
protein heterodimerization activity
protein dimerization activity
general transcription factor
negative regulation of transcription from RNA polymerase II promoter
kidney development
renal water homeostasis
glucose metabolic process
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
apoptotic process
positive regulation of cell proliferation
negative regulation of cell proliferation
response to lithium ion
retina layer formation
magnesium ion homeostasis
regulation of BMP signaling pathway
forelimb morphogenesis
hindlimb morphogenesis
positive regulation of urine volume
aorta morphogenesis
response to drug
glucose homeostasis
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of neuron apoptotic process
positive regulation of neuron apoptotic process
skin development
fat cell differentiation
regulation of cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
sympathetic nervous system development
regulation of insulin secretion
phosphate ion homeostasis
calcium ion homeostasis
potassium ion homeostasis
sodium ion homeostasis
distal tubule development
collecting duct development
metanephric nephron development
ductus arteriosus closure
cellular ammonia homeostasis
cellular creatinine homeostasis
cellular urea homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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