AP3B1 is a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. Structurally, AP3B1 is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in AP3B1 are associated with Hermansky-Pudlak syndrome type 2.
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Protein Aliases: adapter-related protein complex 3 subunit beta-1; adaptor protein complex AP-3 beta-1 subunit; Adaptor protein complex AP-3 subunit beta-1; adaptor related protein complex 3, beta 1 subunit; Adaptor-related protein complex 3 subunit beta-1; adaptor-related protein complex 3, beta 1 subunit; adaptor-related protein complex AP-3, beta 1 subunit; AP-3 complex beta-3A subunit; AP-3 complex subunit beta-1; ap3; Beta-3A-adaptin; beta3A-adaptin; Clathrin assembly protein complex 3 beta-1 large chain; recombination induced mutation 2
Gene Aliases: ADTB3; ADTB3A; AP-3; AP3B1; AU015684; beta3A; C78395; HPS; HPS2; PE; pearl; rim2
Molecular Function: membrane traffic protein