Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
PA1-29880 detects AP3B2 from human samples.
PA1-29880 has been successfully used in immunocytochemistry applications.
The PA1-29880 immunogen is synthetic peptide: SLLEENAEK AFYGSEEDEA KGAGSEETAA AAAPSRKPYV MDPDHRLLLR NTKPLLQSRSA AVVMAVAQLYFH LAPKAEVGVIAK ALVRLLRS , corresponding to amino acids 259-350 of Human AP3B2.
Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
The AP3 complex is a heterotetramer composed of two large adaptins (AP3D1, AP3B1 or AP3B2), a medium adaptin (AP3M1 or AP3M2) and a small adaptin (APS1 or AP3S2). The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Unlike the homologous AP3B1, AP3B2-containing AP3 complexes are preferentially targeted to neuronal processes, and mice deficient in AP3B2 displayed compromised synaptic zinc stores.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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