Immunogen sequence: PLVVSLIGAL LRDFPNRWEY YLKQLQNKQF KRIRKSSSYD YEALDEAMSI SVEMLREDIK DYYTDLSILQ KDVKVPTKVL CILWDMETEE VEDILQEFVN KSLLFCDR
Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Cell death signals are transduced by death domain containing adaptor molecules and members of the caspase family of proteases. The human and mouse homologues to C. elegans death receptor 4 (CED-4) have recently been isolated and named Apaf-1. Apaf-1 binds to cytochrome C and caspase-9 (also known as Apaf-2 and Apaf-3, respectively), leading to activation of caspase-9. Activated caspase-9 activates caspase-3, leading to the proteolytic cleavage of a number of different proteins involved in the apoptotic cascade. Apaf-1 is ubiquitously expressed in human tissues and has also been shown to interact with caspase-4 and caspase-8.
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Protein Aliases: APAF-1; Apoptotic protease-activating factor 1; CED4
Gene Aliases: APAF-1; APAF1; CED4; KIAA0413
UniProt ID: (Human) O14727
Entrez Gene ID: (Human) 317