Search
Proteintech
APBB1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
27874-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
APBB1 fusion protein Ag27434
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Amount
52.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: TAVGPKDLRS AMGEGGGPEP GPANAKWLKE GQNQLRRAAT AHRDQNRNVT LTLAEEASQE PEMAPLGPKG LIHLYSELEL SAHNAANRGL RGPGLIISTQ EQGPDEGEEK AAGEAEEEEE DDDDEEEEED LSSPPGLPEP LESVEAPPRP QALTDGPREH SKSASLLFGM RNSAASDEDS SWATLSQGSP SYGSPEDTDS FWNPNAFETD SDLPAGWMRV QDTSGT
Target Information
The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein, transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: adaptor protein FE65a2; amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65); amyloid beta A4 precursor protein-binding family B member 1; Amyloid beta precursor protein binding family B member 1; Amyloid-beta A4 precursor protein-binding family B member 1; Fe65; Protein Fe65; stat-like protein; unnamed protein product
Gene Aliases: APBB1; FE65; MGC:9072; RIR
UniProt ID: (Human) O00213, (Rat) P46933, (Mouse) Q9QXJ1
Entrez Gene ID: (Human) 322, (Rat) 29722, (Mouse) 11785
beta-amyloid binding
chromatin binding
transcription coactivator activity
protein binding
ubiquitin protein ligase binding
histone binding
low-density lipoprotein particle receptor binding
binding, bridging
proline-rich region binding
transcription factor binding
protein complex binding
histone acetyltransferase binding
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
regulation of transcription, DNA-templated
apoptotic process
smooth muscle contraction
cellular response to DNA damage stimulus
signal transduction
axonogenesis
positive regulation of neuron projection development
positive regulation of apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of protein secretion
negative regulation of cell cycle G1/S phase transition
neuron migration
double-strand break repair
transcription, DNA-templated
cell cycle arrest
axon guidance
visual learning
response to iron ion
extracellular matrix organization
negative regulation of cell growth
histone H4 acetylation
negative regulation of neuron differentiation
positive regulation of DNA repair
negative regulation of thymidylate synthase biosynthetic process
chromatin modification
actin filament-based movement
protein stabilization
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support