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Alomone Labs, LTD
KV3.1b (KCNC1) Polyclonal Antibody
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Product Details
APC-014-50UL
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
CKESPVIAKYMPTEAVRVT, corresponding to amino acid residues 567-585 of rat KV3.1b, Intracellular, C-terminus
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
40 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: NGK2; Potassium channel gene 1 (alternative splicing product described in Luneau et al 1991); potassium channel, voltage gated Shaw related subfamily C, member 1; potassium voltage gated channel, Shaw-related subfamily, member 1; Potassium voltage-gated channel subfamily C member 1; RAW2; Voltage-gated potassium channel KCNC1; voltage-gated potassium channel protein KV3.1; Voltage-gated potassium channel subunit Kv3.1; Voltage-gated potassium channel subunit Kv4
Gene Aliases: C230009H10Rik; EPM7; KCNC1; Kcr2-1; KShIIIB; KV3.1; KV4; NGK2; NGK2-KV4; Shaw
UniProt ID: (Human) P48547, (Mouse) P15388, (Rat) P25122
Entrez Gene ID: (Human) 3746, (Mouse) 16502, (Rat) 25327
ion channel activity
voltage-gated potassium channel activity
delayed rectifier potassium channel activity
potassium channel activity
protein binding
kinesin binding
gated channel activity
ion channel binding
voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
voltage-gated ion channel activity
voltage-gated ion channel
action potential
ion transport
potassium ion transport
response to toxic substance
response to light intensity
response to auditory stimulus
response to amine
cerebellum development
optic nerve development
globus pallidus development
corpus callosum development
ion transmembrane transport
regulation of ion transmembrane transport
positive regulation of ion transmembrane transport
response to potassium ion
protein homooligomerization
protein tetramerization
transmembrane transport
cellular response to xenobiotic stimulus
response to fibroblast growth factor
potassium ion transmembrane transport
regulation of presynaptic membrane potential
regulation of potassium ion transmembrane transport
positive regulation of potassium ion transmembrane transport
response to nerve growth factor
transport
brain development
cellular response to drug
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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