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CD117 Monoclonal Antibody (104D2), APC

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CD117 Monoclonal Antibody (104D2), APC

Product Details

APC-65154100TST

Applications
Tested Dilution
Publications

Flow Cytometry (Flow)

10 µL/1x10^6 cells in a 100 µL suspension
-
Product Specifications

Species Reactivity

Bovine, Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

104D2

Conjugate

APC APC APC

Excitation/Emission Max

651/660 nm View spectra spectra

Form

Liquid

Concentration

10 µL/Test

Purification

Size-exclusion chromatography

Storage buffer

PBS, pH 7.2

Contains

0.1% sodium azide

Storage conditions

4°C, store in dark

Shipping conditions

Wet ice

Target Information

KIT (c-KIT) is a proto-oncogene and a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). KIT was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. KIT together with its ligand regulates growth and activation of a variety of hemopoietic and non-hemopoietic cells. Mutations in KIT are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Recently, deregulation of the KIT receptor TK by the prevalent activation loop mutation D816V has served as a focal point in therapeutic strategies aimed at curbing neoplastic mast cell growth. c-Kit is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-Kit protooncogene; c-kit receptor; CD117; ckit; mast cell growth factor receptor; Mast/stem cell growth factor receptor Kit; p145 c-kit; PBT; Piebald trait protein; protein kinase; Proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; SCFR; Tyrosine-protein kinase Kit; unnamed protein product; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein

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Gene Aliases: C-Kit; CD117; KIT; MASTC; PBT; SCFR

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UniProt ID: (Human) P10721

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Entrez Gene ID: (Bovine) 280832, (Human) 3815

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Function(s)
transmembrane receptor protein tyrosine kinase activity ATP binding cytokine binding metal ion binding nucleotide binding protease binding protein kinase activity protein tyrosine kinase activity stem cell factor receptor activity protein binding kinase activity transferase activity growth factor binding SH2 domain binding protein homodimerization activity transmembrane signal receptor
Process(es)
activation of MAPK activity ovarian follicle development immature B cell differentiation dendritic cell cytokine production inflammatory response spermatogenesis regulation of cell shape peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway lamellipodium assembly T cell differentiation erythrocyte differentiation melanocyte differentiation actin cytoskeleton reorganization mast cell cytokine production embryonic hemopoiesis megakaryocyte development Fc receptor signaling pathway Kit signaling pathway erythropoietin-mediated signaling pathway mast cell degranulation pigmentation digestive tract development stem cell differentiation detection of mechanical stimulus involved in sensory perception of sound cell chemotaxis mast cell differentiation melanocyte migration melanocyte adhesion hematopoietic progenitor cell differentiation myeloid progenitor cell differentiation lymphoid progenitor cell differentiation mast cell chemotaxis positive regulation of cytokine production involved in immune response positive regulation of dendritic cell cytokine production glycosphingolipid metabolic process chemotaxis signal transduction transmembrane receptor protein tyrosine kinase signaling pathway spermatid development cell proliferation positive regulation of cell proliferation germ cell migration gonad development visual learning male gonad development response to radiation positive regulation of gene expression programmed cell death cell migration stem cell population maintenance actin cytoskeleton organization hemopoiesis B cell differentiation positive regulation of cell migration positive regulation of pseudopodium assembly positive regulation of mast cell cytokine production somatic stem cell population maintenance ectopic germ cell programmed cell death intracellular signal transduction hematopoietic stem cell migration regulation of cell proliferation positive regulation of tyrosine phosphorylation of STAT protein negative regulation of programmed cell death positive regulation of MAPK cascade tongue development leukocyte activation positive regulation of Notch signaling pathway positive regulation of JAK-STAT cascade response to cadmium ion protein autophosphorylation developmental pigmentation positive regulation of long-term neuronal synaptic plasticity epithelial cell proliferation regulation of developmental process positive regulation of sequence-specific DNA binding transcription factor activity negative regulation of developmental process positive regulation of protein kinase B signaling mast cell proliferation positive regulation of mast cell proliferation positive regulation of pyloric antrum smooth muscle contraction regulation of bile acid metabolic process positive regulation of colon smooth muscle contraction positive regulation of small intestine smooth muscle contraction positive regulation of vascular smooth muscle cell differentiation negative regulation of reproductive process
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