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Bethyl Laboratories
APC Polyclonal Antibody
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Product Details
A300-981A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 2793 and the C-terminus (residue 2843) of human adenomatosis polyposis coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adenomatosis polyposis coli tumor suppressor; adenomatous polyposis coli; adenomatous polyposis coli (APC); Adenomatous polyposis coli protein; APC; APC, WNT signaling pathway regulator; Deleted in polyposis 2.5; epididymis secretory sperm binding protein; FAP; FPC; Protein APC; protein phosphatase 1, regulatory subunit 46; Unknown; unnamed protein product; WNT signaling pathway regulator
Gene Aliases: APC; BTPS2; DESMD; DP2; DP2.5; DP3; GS; PPP1R46
UniProt ID: (Human) P25054
Entrez Gene ID: (Human) 324
mitotic cytokinesis
cell fate specification
heart valve development
endocardial cushion morphogenesis
cellular response to DNA damage stimulus
negative regulation of microtubule depolymerization
mitotic spindle assembly checkpoint
cell adhesion
pattern specification process
nervous system development
negative regulation of cell proliferation
insulin receptor signaling pathway
Wnt signaling pathway
cell migration
negative regulation of Wnt signaling pathway
positive regulation of cell migration
positive regulation of pseudopodium assembly
regulation of microtubule-based process
positive regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of protein catabolic process
negative regulation of cyclin-dependent protein serine/threonine kinase activity
regulation of attachment of spindle microtubules to kinetochore
regulation of microtubule-based movement
protein-containing complex assembly
bicellular tight junction assembly
regulation of primary metabolic process
negative regulation of canonical Wnt signaling pathway
positive regulation of cold-induced thermogenesis
negative regulation of cell cycle G1/S phase transition
positive regulation of protein localization to centrosome
negative regulation of G1/S transition of mitotic cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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