A suggested positive control is NIH-3T3 cell lysate.
PA5-20955 can be used with blocking peptide PEP-1069.
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC11 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC11, together with APC2 and Ubc4, form the minimal APC ubiquitin ligase module.
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Protein Aliases: anaphase promoting complex subunit 11 (yeast APC11 homolog); anaphase promoting complex subunit 11 homolog; Anaphase-promoting complex subunit 11; APC11; APC11 anaphase promoting complex subunit 11 homolog; Cyclosome subunit 11; Hepatocellular carcinoma-associated RING finger protein; HSPC214, APC11, Apc11p
Gene Aliases: 1110011I19Rik; ANAPC11; APC11; Apc11p; HSPC214; R75218; RGD1561880