Immunogen sequence: GQLSLLGSDVD GPSLAKAPIS APFVHEGLGV AVGGFPASRH GSPSRSARVP PFNYVPSPMV VAATTDSAAE K
Highest antigen sequence identity to the following orthologs - mouse 67%, rat 77%.
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC2 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. Like APC11, APC2 contains cullin and RING finger domains that are thought to be important in regulating ubiquitination activity.
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Protein Aliases: adenomatosis polyposis coli 2; adenomatous polyposis coli like; Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; APC-like
Gene Aliases: APC2; APCL
UniProt ID: (Human) O95996
Entrez Gene ID: (Human) 10297