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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 19 amino acid peptide near the carboxy terminus of human APC3.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunohistochemistry (IHC)||5 µg/ml|
|Western Blot (WB)||1-2 ug/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is mouse liver tissue lysate.
PA5-20942 can be used with blocking peptide PEP-1056.
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC3, also known as CDC27, a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), is a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. APC3 contains a tetratricopeptide repeat (TPR) region and interacts with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
ANAPC3, APC3, CDC27Hs, D0S1430E, D17S978E, HNUC, NUC2; anaphase promoting complex subunit 3; anaphase-promoting complex subunit 3; anaphase-promoting complex, protein 3; cell division cycle 27 homolog; cell division cycle protein 27 homolog; nuc2 homolog
AI452358; ANAPC3; APC3; BC023187; CDC27; CDC27Hs; D0S1430E; D17S978E; H-NUC; HNUC; NUC2