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|Tested species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide corresponding to the N terminus amino acids PKRGKKGAVAEDGD.|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||4-6µg/ml|
|Western Blot (WB)||0.1-0.3µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
This antibody is predicted to react with bovine, canine and porcine based on sequence homology.
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
AP endonuclease class I; AP lyase; APE; APE1; APEN; APEX; APEX nuclease (multifunctional DNA repair enzyme); APEX nuclease (multifunctional DNA repair enzyme) 1; APEX1; apurinic-apyrimidinic endonuclease 1; apurinic/a; apurinic/apyrimidinic (abasic) endonuclease; deoxyribonuclease (apurinic or apyrimidinic); HAP1; protein REF-1; redox factor-1; REF1
APE; APE1; APEN; APEX; APEX1; APX; HAP1; REF1