This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA5-29157 targets APE1 in IF, IHC (P), and WB applications and shows reactivity with Human, Rat, and mouse samples.
The PA5-29157 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 318 of Human APE1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.
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Protein Aliases: AP endonuclease 1; AP endonuclease class I; AP lyase; APE1; APEN; APEX; APEX nuclease; APEX nuclease (multifunctional DNA repair enzyme) 1; APEX nuclease 1; Apurinic-apyrimidinic endonuclease 1; apurinic/apyrimidinic (abasic) endonuclease; apurinic/apyrimidinic endonuclease 1; deoxyribonuclease (apurinic or apyrimidinic); DNA-(apurinic or apyrimidinic site) lyase; DNA-(apurinic or apyrimidinic site) lyase, mitochondrial; HAP1; protein REF-1; Redox factor-1; REF-1; REF1
Gene Aliases: APE; APE1; APEN; APEX; APEX1; APX; HAP1; REF-1; REF1