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Invitrogen
APEX2 Polyclonal Antibody
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Product Details
PA1-41306
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptides of human APEX2 (aa 122-140 and 438-455).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
200 µg
Purification
Protein G
Storage buffer
PBS with 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Suggested positive control: Hela whole cell extract.
Predicted cross-reactivity based on sequence identity (not validated): Mouse, Rat.
Immunogen sequence: EELRALDSEG RALLTQHKI & GQAKTSEAKD EKELRTSF
Target Information
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AP endonuclease 2; AP endonuclease XTH2; APEX nuclease (apurinic/apyrimidinic endonuclease) 2; APEX nuclease 2; APEX nuclease-like 2; apurinic endonuclease; Apurinic-apyrimidinic endonuclease 2; apurinic/apyrimidinic endonuclease-like 2; DNA-(apurinic or apyrimidinic site) endonuclease 2; DNA-(apurinic or apyrimidinic site) lyase 2; RP5-884M20.3; unnamed protein product; zinc finger, GRF-type containing 2
Gene Aliases: APE2; APEX2; APEXL2; XTH2; ZGRF2
UniProt ID: (Human) Q9UBZ4
Entrez Gene ID: (Human) 27301
DNA binding
catalytic activity
DNA-(apurinic or apyrimidinic site) lyase activity
nuclease activity
endonuclease activity
exonuclease activity
protein binding
phosphoric diester hydrolase activity
zinc ion binding
double-stranded DNA 3'-5' exodeoxyribonuclease activity
hydrolase activity
metal ion binding
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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