PA1-2010 detects APH-1 in human and mouse samples.
PA1-2010 has been successfully used in immunofluorescent, immunoprecipitation, and Western blot procedures. By Western blot, this antibody detects a ~28 kDa protein representing APH-1 in mouse brain and kidney extracts.
The PA1-2010 immunogen is a Synthetic peptide, KLH conjugated, corresponding to residues C (245) R R Q E D S R V M V Y S A L R I P P E D (265) of the C-Terminal domain of the long isoform of APH-1a. This polyclonal antibody has been referred to as, O2C2 in the reference listed above.
Familial Alzheimer's disease is often characterized by an early (<60 years of age) and rapid deterioration of the central nervous system. The symptoms are caused by the abnormal buildup of senile plaques composed of the 42 residue amyloid-beta peptide. This peptide is the result of the amyloid precursor protein being cleaved by the presenilin-gamma-secretase complex. APH-1 has been found to be a member of the presenilin (PS) complex, and likely contributes to the gamma-secretase activity involved with the onset of Alzheimer's. Recent evidence has shown that APH-1 also plays a role in the maturation of nicastrin/presenilin complexes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: anterior pharynx defective 1 homolog A; Aph-1; aph-1 homolog A, gamma secretase subunit; APH-1a; Aph-1alpha; Aph1; APH1A gamma secretase subunit; Gamma-secretase subunit APH-1A; Presenilin-stabilization factor
Gene Aliases: 6530402N02Rik; APH-1; APH-1A; APH1A; CGI-78; PSF; UNQ579/PRO1141
Molecular Function: enzyme modulator