This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology.
APH1 is a multipass transmembrane protein that interacts with presenilin and nicastrin as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein and Notch .
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 6530402N02Rik; anterior pharynx defective 1 homolog A; anterior pharynx defective 1 homolog A (C. elegans); aph-1 homolog A, gamma secretase subunit; APH-1A; Aph-1alpha; APH1A; APH1A gamma secretase subunit; CGI-78; Gamma-secretase subunit APH-1A; Presenilin-stabilization factor
Gene Aliases: 6530402N02Rik; APH-1; APH-1A; APH1A; CGI-78; PSF; UNQ579/PRO1141
UniProt ID: (Human) Q96BI3
Entrez Gene ID: (Human) 51107
Molecular Function: enzyme modulator