For Western Blot, this antibody has non-specific bands at 31 kDa and 75 kDa.
APH1 is a multipass transmembrane protein that interacts with presenilin and nicastrin as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein and Notch .
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: anterior pharynx defective 1 homolog A; anterior pharynx defective 1a homolog; aph-1 homolog A, gamma secretase subunit; APH-1a; Aph-1alpha; APH1A gamma secretase subunit; Gamma-secretase subunit APH-1A; Presenilin-stabilization factor; RP4-790G17.3, 6530402N02Rik, APH-1, APH-1A, CGI-78, aph-1alpha
Gene Aliases: 6530402N02Rik; APH-1; APH-1A; APH1A; CGI-78; PSF; RGD1311546; UNQ579/PRO1141
Molecular Function: enzyme modulator